POTENTIAL OF INDIGENOUS PROBIOTIC Lactobacillus plantarum Dad 13 AS ANTI‐DIARRHEA AND IMMUNO‐MODULATOR

Abstract

The purpose of the research were to study the effectivity of selected indigenous probiotic Lactobacillus
plantarum Dad 13 against enteropathogenic E. coli causing diarrhea in vivo as well as sinbiotic immunomodulatory
properties of purple sweet potato extract probiotic yogurt on blood and liver MDA levels in
albino Norway rats (Rattus novergicus) Sprague dawley strain. Unidirection factorial completely randomized
design was applied during study with several variables: purple sweet potato yogurt without probiotics
addition (P0) and with probiotic addition (P1), where the latter was conducted on two groups of Sprague
Dawley rats treated with or without EPEC ATCC 35218 enteropathogenic Escherichia coli (E1 or E0, respectively).
Results showed that there was interaction between indigenous probiotic addition in purple sweet
potato yogurt and EPEC ATCC 35218 on faecal water content after 1 week treatment with EPEC ATCC
35218, cecum water content, and MDA level of blood and liver of experimental animals at the end of the
study. Besides, culture of Lactobacillus plantarum Dad 13 added to purple sweet potato extract yogurt was
able to provide preventive health effects as antiâ€diarrhea and immunomodulatory agent.
Keywords: Probiotic, Antiâ€diarrhea, Immunoâ€modulator